Regulation of NK cell cytotoxicity during pregnancy

Regulation of NK Cell-Mediated Cytotoxicity

during NK Cell-Mediated Cytotoxicity Dynamin 2 Regulates Granule Exocytosis

Augmentation of NK cell-mediated cytotoxicity to tumor cells by inhibitory NK cell receptor blockers.

NK cells monitor expression of MHC class I by inhibitory receptors and preferentially kill cells that lose or down-regulate MHC class I expression. One possible mechanism by which tumor cells evade NK cell killing is continued expression of appropriate MHC class I ligands to engage inhibitory receptors on NK cells. We show here that small-mol.-wt blockers against the mouse inhibitory NK cell re...

Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk.

NK cells are effector lymphocytes that can recognize and eliminate virally infected and transformed cells. NK cells express distinct activating receptors, including an ITAM-containing FcR complex that recognizes Ab-coated targets, and the DNAX-activating protein of 10 kDa-containing NKG2D receptor complex that recognizes stress-induced ligands. The regulatory role of specific tyrosine kinases i...

Kinase Itk Cell-Mediated Cytotoxicity by the Tyrosine Differential Regulation of Human NK